BIOGRAPHICAL SKETCH · Prof. Trine Grønhaug Halvorsen

Department of Pharmacy
University of Oslo
Norway

Trine Grønhaug Halvorsen is professor in pharmaceutical analysis with a main research interest in development of new sampling and sample preparation tools and strategies for determination of proteins; biomarkers, biopharmaceuticals and doping agents, in biological matrices by mass spectrometry. The goal being to enable robust determination of low levels of proteins in limited volumes of biological samples. She has more than ten years of experience in use and evaluation of different affinity based sample clean-up approaches for bottom-up determination of low-abundant proteins. She has evaluated both antibodies and molecularly imprinted polymers for this purpose. She also has strong background in microsampling, and especially dried blood spot (DBS) sampling for use in mass spectrometric protein analysis. Focus has been on both evaluation of DBS sampling in protein analysis and development and evaluation of novel and smart sampling materials. These smart sampling materials integrate some of the tedious sample preparation steps  in protein analysis such as tryptic proteolysis or affinity capture in the sampling step. Other research interests include use of novel ionization techniques, eg. matrix assisted ionization and solvent assisted ionization in targeted protein analysis.